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Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II

X-ray diffraction
1.8Å resolution
PDB entry 3ow9 coloured by chain, front view.
PDB entry 3ow9 coloured by chain, side view.
PDB entry 3ow9 coloured by chain, top view.
Source organism: synthetic construct
Assembly composition:
homo dodecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble APP-beta
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Multimeric state: homo dodecamer
Accessible surface area: 4343.7 Å2
Buried surface area: 7817.83 Å2
Dissociation area: 2,117.76 Å2
Dissociation energy (ΔGdiss): 23 kcal/mol
Dissociation entropy (TΔSdiss): 27.32 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138392

Macromolecules

P3(40)
Chains: A, B
Length: 6 amino acids
Theoretical weight: 725 Da
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 687-692; Coverage: 1%)
Gene names: A4, AD1, APP
P3(40) in PDB entry 3ow9, assembly 1, front view.
P3(40) in PDB entry 3ow9, assembly 1, side view.
P3(40) in PDB entry 3ow9, assembly 1, top view.
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