PDBe 3ovz

X-ray diffraction
2.02Å resolution

Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead

Released:

Function and Biology Details

Reaction catalysed:
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin K Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P43235 (Residues: 121-329; Coverage: 67%)
Gene names: CTSK, CTSO, CTSO2
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P43212
Unit cell:
a: 55.741Å b: 55.741Å c: 128.916Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.244 0.308
Expression system: Not provided