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Crystal Structure of hRPE and D-Ribulose-5-Phospate Complex

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: pentose-phosphate shunt, non-oxidative branch
Cellular component: extracellular exosome

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EC 5.1.3.1: Ribulose-phosphate 3-epimerase

Reaction catalysed:
D-ribulose 5-phosphate = D-xylulose 5-phosphate
Systematic name:
D-ribulose-5-phosphate 3-epimerase
Alternative Name(s):
  • D-ribulose 5-phosphate epimerase
  • D-ribulose phosphate-3-epimerase
  • D-ribulose-5-P 3-epimerase
  • D-ribulose-5-phosphate epimerase
  • D-xylulose-5-phosphate 3-epimerase
  • Erythrose-4-phosphate epimerase
  • Erythrose-4-phosphate isomerase
  • Pentose-5-phosphate 3-epimerase
  • Phosphoketopentose 3-epimerase
  • Phosphoketopentose epimerase
  • Phosphoribulose epimerase
  • Ribulose 5-phosphate 3-epimerase
  • Xylulose phosphate 3-epimerase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00834
Domain description: Ribulose-phosphate 3 epimerase family
Occurring in:
  1. Ribulose-phosphate 3-epimerase
The deposited structure of PDB entry 3ovq contains 2 copies of Pfam domain PF00834 (Ribulose-phosphate 3 epimerase family) in Ribulose-phosphate 3-epimerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000056
Domain description: Ribulose-phosphate 3-epimerase-like
Occurring in:
  1. Ribulose-phosphate 3-epimerase
IPR026019
Domain description: Ribulose-phosphate 3-epimerase
Occurring in:
  1. Ribulose-phosphate 3-epimerase
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. Ribulose-phosphate 3-epimerase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Ribulose-phosphate 3-epimerase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Ribulose-phosphate 3-epimerase
The deposited structure of PDB entry 3ovq contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Ribulose-phosphate 3-epimerase. Showing 1 copy in chain A.

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