PDBe 3og6

X-ray diffraction
2.1Å resolution

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon lambda-1 Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 22 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8IU54 (Residues: 20-200; Coverage: 100%)
Gene names: IFNL1, IL29, ZCYTO21
Sequence domains: Interleukin-28A
Structure domains: Growth Hormone; Chain: A;
Interferon lambda receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 226 amino acids
Theoretical weight: 25.32 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8IU57 (Residues: 19-226; Coverage: 41%)
  • Best match: Q8IU57-4 (Residues: 19-223)
Gene names: IFNLR1, IL28RA, LICR2
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 64.96Å b: 85.79Å c: 116.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.184 0.228
Expression system: Drosophila melanogaster