PDBe 3oef

X-ray diffraction
1.6Å resolution

Crystal structure of Y323F inactive mutant of p38alpha MAP kinase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: X
Molecule details ›
Chain: X
Length: 360 amino acids
Theoretical weight: 41.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
  • Best match: Q16539-3 (Residues: 1-280)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 64.734Å b: 69.07Å c: 74.409Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.183 0.221
Expression system: Escherichia coli