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The structure of the complex between complement receptor CR2 and its ligand complement fragment C3d

X-ray diffraction
3.16Å resolution
PDB entry 3oed coloured by chain, front view.
PDB entry 3oed coloured by chain, side view.
PDB entry 3oed coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement C3b complex and Complement receptor type 2
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Multimeric state: hetero dimer
Accessible surface area: 18259.22 Å2
Buried surface area: 2241.21 Å2
Dissociation area: 1,120.61 Å2
Dissociation energy (ΔGdiss): -6.45 kcal/mol
Dissociation entropy (TΔSdiss): 12.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133844
Assembly 2
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Assembly Name: Complement C3b complex and Complement receptor type 2
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Multimeric state: hetero dimer
Accessible surface area: 18569.21 Å2
Buried surface area: 2150.16 Å2
Dissociation area: 1,075.08 Å2
Dissociation energy (ΔGdiss): -6.22 kcal/mol
Dissociation entropy (TΔSdiss): 12.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133844

Macromolecules

Complement C3d fragment
Chains: A, B
Length: 310 amino acids
Theoretical weight: 34.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01024 (Residues: 996-1303; Coverage: 19%)
Gene names: C3, CPAMD1
Pfam: A-macroglobulin TED domain
InterPro:
CATH: Glycosyltransferase
Complement C3d fragment in PDB entry 3oed, assembly 1, front view.
Complement C3d fragment in PDB entry 3oed, assembly 1, side view.
Complement C3d fragment in PDB entry 3oed, assembly 1, top view.
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Complement receptor type 2
Chains: C, D
Length: 135 amino acids
Theoretical weight: 14.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P20023 (Residues: 19-153; Coverage: 13%)
Gene names: C3DR, CR2
Pfam: Sushi repeat (SCR repeat)
InterPro:
CATH: Complement Module, domain 1
Complement receptor type 2 in PDB entry 3oed, assembly 1, front view.
Complement receptor type 2 in PDB entry 3oed, assembly 1, side view.
Complement receptor type 2 in PDB entry 3oed, assembly 1, top view.
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