PDBe 3odi

X-ray diffraction
2.2Å resolution

Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Voclosporin Chains: B, D, F, H, J, L, N, P, R, T
Molecule details ›
Chains: B, D, F, H, J, L, N, P, R, T
Length: 11 amino acids
Theoretical weight: 1.23 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided
Peptidyl-prolyl cis-trans isomerase A Chains: A, C, E, G, I, K, M, O, Q, S
Molecule details ›
Chains: A, C, E, G, I, K, M, O, Q, S
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P21
Unit cell:
a: 69.179Å b: 161.341Å c: 93.654Å
α: 90° β: 100.06° γ: 90°
R R work R free
0.166 0.164 0.22
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)