PDBe 3oct

X-ray diffraction
1.95Å resolution

Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib

Released:
Source organism: Homo sapiens
Entry authors: Davies DR, Staker BL

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 30.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 393-656; Coverage: 40%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 54.101Å b: 42.944Å c: 64.542Å
α: 90° β: 112.58° γ: 90°
R-values:
R R work R free
0.199 0.196 0.251
Expression system: Spodoptera frugiperda