PDBe 3obj

X-ray diffraction
2.4Å resolution

Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding

Source organism: Homo sapiens
Entry authors: Namboodiri HV, Karpusas M, Bukhtiyarova M, Springman EB

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-002+
Spacegroup: P212121
Unit cell:
a: 68.319Å b: 69.839Å c: 76.088Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.215 0.287
Expression system: Escherichia coli