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Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding

X-ray diffraction
2.1Å resolution
PDB entry 3o8u coloured by chain, front view.
PDB entry 3o8u coloured by chain, side view.
PDB entry 3o8u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 14
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Multimeric state: monomeric
Accessible surface area: 16787.26 Å2
Buried surface area: 1482.44 Å2
Dissociation area: 364.82 Å2
Dissociation energy (ΔGdiss): -8.56 kcal/mol
Dissociation entropy (TΔSdiss): 4.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172487

Macromolecules

Mitogen-activated protein kinase 14
Chain: A
Length: 360 amino acids
Theoretical weight: 41.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 14 in PDB entry 3o8u, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 3o8u, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 3o8u, assembly 1, top view.
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