PDBe 3o5x

X-ray diffraction
2Å resolution

Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 32.28 KDa
Source organism: Homo sapiens
  • Canonical: Q06124 (Residues: 262-532; Coverage: 45%)
  • Best match: Q06124-3 (Residues: 262-459)
Gene names: PTP2C, PTPN11, SHPTP2
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 39.544Å b: 75.829Å c: 48.214Å
α: 90° β: 98.53° γ: 90°
R R work R free
0.196 0.196 0.238