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Crystal structure of TRIM24 PHD-Bromo complexed with H3(23-31)K27ac peptide

X-ray diffraction
1.76Å resolution
PDB entry 3o35 coloured by chain, front view.
PDB entry 3o35 coloured by chain, side view.
PDB entry 3o35 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone H3.1 and Transcription intermediary factor 1-alpha
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Multimeric state: hetero dimer
Accessible surface area: 10845.7 Å2
Buried surface area: 590.25 Å2
Dissociation area: 295.13 Å2
Dissociation energy (ΔGdiss): -0.71 kcal/mol
Dissociation entropy (TΔSdiss): 5.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127339
Assembly 2
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Assembly Name: Histone H3.1 and Transcription intermediary factor 1-alpha
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Multimeric state: hetero dimer
Accessible surface area: 10663.77 Å2
Buried surface area: 392.65 Å2
Dissociation area: 196.32 Å2
Dissociation energy (ΔGdiss): 1.3 kcal/mol
Dissociation entropy (TΔSdiss): 2.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127339

Macromolecules

Transcription intermediary factor 1-alpha
Chains: A, B
Length: 184 amino acids
Theoretical weight: 21.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15164 (Residues: 824-1006; Coverage: 17%)
Gene names: RNF82, TIF1, TIF1A, TRIM24
Pfam:
InterPro:
CATH:
Transcription intermediary factor 1-alpha in PDB entry 3o35, assembly 1, front view.
Transcription intermediary factor 1-alpha in PDB entry 3o35, assembly 1, side view.
Transcription intermediary factor 1-alpha in PDB entry 3o35, assembly 1, top view.
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Histone H3.1
Chains: D, E
Length: 9 amino acids
Theoretical weight: 943 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 24-32; Coverage: 7%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Histone H3.1 in PDB entry 3o35, assembly 1, front view.
Histone H3.1 in PDB entry 3o35, assembly 1, side view.
Histone H3.1 in PDB entry 3o35, assembly 1, top view.
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