PDBe 3nzs

X-ray diffraction
2.75Å resolution

Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 144.966Å b: 67.965Å c: 106.989Å
α: 90° β: 95.57° γ: 90°
R R work R free
0.212 0.21 0.243
Expression system: Spodoptera frugiperda