PDBe 3nz0

X-ray diffraction
2Å resolution

Non-phosphorylated TYK2 kinase with CMP6

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-receptor tyrosine-protein kinase TYK2 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29597 (Residues: 885-1176; Coverage: 25%)
Gene name: TYK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 56.59Å b: 64.91Å c: 83.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.253
Expression system: Spodoptera frugiperda