› 3nyx

X-ray diffraction
2.5Å resolution

Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor

Released:
DOI: 10.2210/pdb3nyx/pdb
PDB entry 3nyx coloured by chain, front view.
PDB entry 3nyx coloured by chain, side view.
PDB entry 3nyx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A new regulatory switch in a JAK protein kinase.
Tsui V, Gibbons P, Ultsch M, Mortara K, Chang C, Blair W, Pulk R, Stanley M, Starovasnik M, Williams D, Lamers M, Leonard P, Magnuson S, Liang J, Eigenbrot C
Proteins 79 393-401 (2011)
PMID: 21117080

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-receptor tyrosine-protein kinase TYK2 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29597 (Residues: 885-1176; Coverage: 25%)
Gene name: TYK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand TZ1 1 x TZ1
Ligand DTT 2 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 55.318Å b: 70.436Å c: 86.488Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.215 0.275
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Therapeutic potential of tyrosine kinase 2 in autoimmunity.
Liang et al. (2014)
10 other articles

4 mentions without citation

Relative Binding Free Energy Calculations Applied to Protein Homology Models.
Cappel et al. (2016)
3 more