PDBe 3nw5

X-ray diffraction
2.14Å resolution

Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11B)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P08069 (Residues: 982-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: C2
Unit cell:
a: 106.642Å b: 41.289Å c: 78.183Å
α: 90° β: 120.21° γ: 90°
R-values:
R R work R free
0.196 0.193 0.254
Expression system: unidentified baculovirus