› 3nha

X-ray diffraction
2.1Å resolution

Nucleotide Binding Domain of Human ABCB6 (ADP Mg bound structure)

Released:
DOI: 10.2210/pdb3nha/pdb
PDB entry 3nha coloured by chain, front view.
PDB entry 3nha coloured by chain, side view.
PDB entry 3nha coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides.
Haffke M, Menzel A, Carius Y, Jahn D, Heinz DW
Acta Crystallogr D Biol Crystallogr 66 979-87 (2010)
PMID: 20823549

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + heme(Side 1) = ADP + phosphate + heme(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family B member 6 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 33.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NP58 (Residues: 558-842; Coverage: 34%)
Gene names: ABCB6, MTABC3, PRP, UMAT
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

4 bound ligands:
Ligand PO4 1 x PO4
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand BME 2 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 56.272Å b: 70.708Å c: 71.113Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.252
Expression system: Escherichia coli

Quick links

Citations

1 review citation

20,000 picometers under the OMM: diving into the vastness of mitochondrial metabolite transport.
Cunningham et al. (2020)
8 other articles