PDBe 3nga

X-ray diffraction
2.71Å resolution

Human CK2 catalytic domain in complex with CX-4945

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 39.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68400 (Residues: 1-333; Coverage: 85%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P43212
Unit cell:
a: 127.64Å b: 127.64Å c: 125.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.218
Expression system: Escherichia coli BL21(DE3)