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Crystal structure of WDR5 mutant (W330F)

X-ray diffraction
2.3Å resolution
PDB entry 3n0d coloured by chain, front view.
PDB entry 3n0d coloured by chain, side view.
PDB entry 3n0d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5
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Multimeric state: monomeric
Accessible surface area: 12395.21 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158474

Macromolecules

WD repeat-containing protein 5
Chain: A
Length: 315 amino acids
Theoretical weight: 34.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 31-334; Coverage: 91%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 3n0d, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 3n0d, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 3n0d, assembly 1, top view.
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