PDBe 3mvj

X-ray diffraction
2.49Å resolution

Human cyclic AMP-dependent protein kinase PKA inhibitor complex


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
cAMP-dependent protein kinase inhibitor alpha Chains: I, J, K
Molecule details ›
Chains: I, J, K
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P61925 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
cAMP-dependent protein kinase catalytic subunit alpha Chains: A, B, E
Molecule details ›
Chains: A, B, E
Length: 371 amino acids
Theoretical weight: 42.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P17612 (Residues: 1-351; Coverage: 100%)
Gene names: PKACA, PRKACA
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P212121
Unit cell:
a: 61.163Å b: 120.828Å c: 162.415Å
α: 90° β: 90° γ: 90°
R R work R free
0.217 0.212 0.304
Expression systems:
  • Not provided
  • Spodoptera frugiperda