PDBe 3mpa

X-ray diffraction
2.1Å resolution

Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding

Released:
Source organism: Homo sapiens
Entry authors: Namboodiri HV, Karpusas M, Bukhtiyarova M, Springman EB

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 65.471Å b: 74.144Å c: 77.184Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.23 0.289
Expression system: Not provided