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Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2

Source organism: Saccharomyces cerevisiae
Biochemical function: not assigned
Biological process: ubiquitin-dependent protein catabolic process
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Cell division control protein 4
The deposited structure of PDB entry 3mks contains 10 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Cell division control protein 4. Showing 5 copies in chain D.

PF03931
Domain description: Skp1 family, tetramerisation domain
Occurring in:
  1. Suppressor of kinetochore protein 1
The deposited structure of PDB entry 3mks contains 4 copies of Pfam domain PF03931 (Skp1 family, tetramerisation domain) in Suppressor of kinetochore protein 1. Showing 2 copies in chain A.

PF00646
Domain description: F-box domain
Occurring in:
  1. Cell division control protein 4
The deposited structure of PDB entry 3mks contains 2 copies of Pfam domain PF00646 (F-box domain) in Cell division control protein 4. Showing 1 copy in chain D.

PF01466
Domain description: Skp1 family, dimerisation domain
Occurring in:
  1. Suppressor of kinetochore protein 1
The deposited structure of PDB entry 3mks contains 2 copies of Pfam domain PF01466 (Skp1 family, dimerisation domain) in Suppressor of kinetochore protein 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Cell division control protein 4
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Cell division control protein 4
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Cell division control protein 4
IPR001810
Domain description: F-box domain
Occurring in:
  1. Cell division control protein 4
IPR016897
Domain description: S-phase kinase-associated protein 1
Occurring in:
  1. Suppressor of kinetochore protein 1
IPR011333
Domain description: SKP1/BTB/POZ domain superfamily
Occurring in:
  1. Suppressor of kinetochore protein 1
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Cell division control protein 4
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Cell division control protein 4
IPR036047
Domain description: F-box-like domain superfamily
Occurring in:
  1. Cell division control protein 4
IPR016072
Domain description: SKP1 component, dimerisation
Occurring in:
  1. Suppressor of kinetochore protein 1
IPR036296
Domain description: SKP1-like, dimerisation domain superfamily
Occurring in:
  1. Suppressor of kinetochore protein 1
IPR016073
Domain description: SKP1 component, POZ domain
Occurring in:
  1. Suppressor of kinetochore protein 1
IPR001232
Domain description: S-phase kinase-associated protein 1-like
Occurring in:
  1. Suppressor of kinetochore protein 1

Structure domains

CATH CATH domains
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Cell division control protein 4
The deposited structure of PDB entry 3mks contains 2 copies of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Cell division control protein 4. Showing 1 copy in chain D.
1.20.1280.50
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Monooxygenase
Homology: Monooxygenase
Occurring in:
  1. Cell division control protein 4
The deposited structure of PDB entry 3mks contains 2 copies of CATH domain 1.20.1280.50 (Monooxygenase) in Cell division control protein 4. Showing 1 copy in chain D.
3.30.710.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Potassium Channel Kv1.1; Chain A
Homology: Potassium Channel Kv1.1; Chain A
Occurring in:
  1. Suppressor of kinetochore protein 1
The deposited structure of PDB entry 3mks contains 2 copies of CATH domain 3.30.710.10 (Potassium Channel Kv1.1; Chain A) in Suppressor of kinetochore protein 1. Showing 1 copy in chain A.

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