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Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state

X-ray diffraction
2.2Å resolution
PDB entry 3mh3 coloured by chain, front view.
PDB entry 3mh3 coloured by chain, side view.
PDB entry 3mh3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 14
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Multimeric state: monomeric
Accessible surface area: 16647.53 Å2
Buried surface area: 714.86 Å2
Dissociation area: 357.43 Å2
Dissociation energy (ΔGdiss): -8.98 kcal/mol
Dissociation entropy (TΔSdiss): 4.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172487

Macromolecules

Mitogen-activated protein kinase 14
Chain: A
Length: 360 amino acids
Theoretical weight: 41.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 14 in PDB entry 3mh3, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 3mh3, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 3mh3, assembly 1, top view.
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