PDBe 3mes

X-ray diffraction
2.35Å resolution

Crystal structure of choline kinase from Cryptosporidium parvum Iowa II, cgd3_2030

Released:
Entry authors: Qiu W, Wernimont A, Hills T, Lew J, Artz JD, Xiao T, Allali-Hassani A, Vedadi M, Kozieradzki I, Cossar D, Bountra C, Weigelt J, Arrowsmith CH, Edwards AM, Hui R, Ma D, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative choline kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 424 amino acids
Theoretical weight: 49.63 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CUP2 (Residues: 1-405; Coverage: 100%)
Gene name: cgd3_2030
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 170.091Å b: 67.957Å c: 92.109Å
α: 90° β: 116.54° γ: 90°
R-values:
R R work R free
0.247 0.245 0.291
Expression system: Escherichia coli