PDBe 3mdz

X-ray diffraction
2.32Å resolution

Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7

Released:
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Shafqat N, Pilka E, Chaikuad A, Krojer T, Muniz J, Kim J, Bray J, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, von Delft F, Carpenter EP, Yue WW, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 7 Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43166 (Residues: 5-262; Coverage: 98%)
Gene name: CA7
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Carbonic Anhydrase II

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 69.71Å b: 97.746Å c: 82.443Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.252
Expression system: Escherichia coli