PDBe 3mdy

X-ray diffraction
2.05Å resolution

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

Released:
Source organism: Homo sapiens
Entry authors: Chaikuad A, Sanvitale C, Mahajan P, Daga N, Cooper C, Krojer T, Alfano I, Knapp S, von Delft F, Weigelt J, Arrowsmith CH, Edwards AM, Bountra C, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: B, D
Molecule details ›
Chains: B, D
Length: 109 amino acids
Theoretical weight: 12.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Bone morphogenetic protein receptor type-1B Chains: A, C
Molecule details ›
Chains: A, C
Length: 337 amino acids
Theoretical weight: 38.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00238 (Residues: 168-502; Coverage: 69%)
Gene name: BMPR1B
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 65.41Å b: 80.01Å c: 183.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.255
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda