PDBe 3mdl

X-ray diffraction
2.2Å resolution

X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2

Released:
Source organism: Mus musculus
Primary publication:
The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J. Biol. Chem. 286 20736-45 (2011)
PMID: 21489986

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 587 amino acids
Theoretical weight: 67.46 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05769 (Residues: 20-599; Coverage: 99%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand COH 2 x COH

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I222
Unit cell:
a: 118.958Å b: 131.773Å c: 179.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.165 0.215
Expression system: Spodoptera frugiperda