EC 1.1.1.42: Isocitrate dehydrogenase (NADP(+))
Reaction catalysed:
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Systematic name:
Isocitrate:NADP(+) oxidoreductase (decarboxylating)
Alternative Name(s):
- Dual-cofactor-specific isocitrate dehydrogenase
- IDH
- IDP
- IDP1
- IDP2
- IDP3
- Isocitrate (NADP) dehydrogenase
- Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
- Isocitrate dehydrogenase (NADP)
- Isocitrate dehydrogenase (NADP-dependent)
- NADP isocitric dehydrogenase
- NADP(+)-ICDH
- NADP(+)-IDH
- NADP(+)-linked isocitrate dehydrogenase
- NADP-dependent isocitrate dehydrogenase
- NADP-dependent isocitric dehydrogenase
- NADP-linked isocitrate dehydrogenase
- NADP-specific isocitrate dehydrogenase
- Oxalosuccinate decarboxylase
- Oxalsuccinic decarboxylase
- Triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase
GO terms
Biochemical function:
- NAD binding
- NADP binding
- metal ion binding
- cadherin binding
- protein homodimerization activity
- identical protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- oxidoreductase activity
- protein binding
- isocitrate dehydrogenase (NADP+) activity
- magnesium ion binding
Biological process:
- regulation of phospholipid biosynthetic process
- regulation of phospholipid catabolic process
- response to steroid hormone
- response to organic cyclic compound
- female gonad development
- response to oxidative stress
- glutathione metabolic process
- NADP metabolic process
- 2-oxoglutarate metabolic process
- isocitrate metabolic process
- tricarboxylic acid cycle
- glyoxylate cycle
Protein family (Pfam)![The deposited structure of PDB entry 3mar contains 2 copies of Pfam domain PF00180 (Isocitrate/isopropylmalate dehydrogenase) in Isocitrate dehydrogenase [NADP] cytoplasmic. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/3mar_1_B_Pfam_PF00180_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3mar</span> contains 2 copies of Pfam domain <span class='highlight'>PF00180 (Isocitrate/isopropylmalate dehydrogenase)</span> in <span class='highlight'>Isocitrate dehydrogenase [NADP] cytoplasmic</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 3mar contains 2 copies of CATH domain 3.40.718.10 (Isopropylmalate Dehydrogenase) in Isocitrate dehydrogenase [NADP] cytoplasmic. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/3mar_1_B_CATH_3.40.718.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3mar</span> contains 2 copies of CATH domain <span class='highlight'>3.40.718.10 (Isopropylmalate Dehydrogenase)</span> in <span class='highlight'>Isocitrate dehydrogenase [NADP] cytoplasmic</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")