PDBe 3m42

X-ray diffraction
2.68Å resolution

Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Scheufler C, Revesz L, Be C, Izaac A, Huppertz C, Schlapbach A, Kroemer M

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-activated protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49137 (Residues: 47-364; Coverage: 74%)
Gene name: MAPKAPK2
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6322
Unit cell:
a: 103.2Å b: 103.2Å c: 166.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.186 0.232
Expression system: Escherichia coli