PDBe 3lw0

X-ray diffraction
1.79Å resolution

IGF-1RK in complex with ligand MSC1609119A-1

Released:
Source organism: Homo sapiens
Primary publication:
Allosteric IGF-1R Inhibitors
ACS Med Chem Lett 1 199-203 (2010)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 304 amino acids
Theoretical weight: 34.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08069 (Residues: 983-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: R3
Unit cell:
a: 189.346Å b: 189.346Å c: 115.92Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.157 0.157 0.185
Expression system: Spodoptera frugiperda