PDBe 3ltg

X-ray diffraction
3.4Å resolution

Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein spitz Chain: D
Molecule details ›
Chain: D
Length: 52 amino acids
Theoretical weight: 6.01 KDa
Source organism: Drosophila melanogaster
Expression system: Drosophila melanogaster
  • Canonical: Q01083 (Residues: 76-126; Coverage: 25%)
Gene names: CG10334, spi
Structure domains: Laminin
Epidermal growth factor receptor Chains: A, C
Molecule details ›
Chains: A, C
Length: 601 amino acids
Theoretical weight: 67.97 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
  • Canonical: P04412 (Residues: 100-688; Coverage: 42%)
Gene names: CG10079, DER, Egfr, c-erbB, top
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 73.75Å b: 120.15Å c: 274.7Å
α: 90° β: 90° γ: 90°
R R work R free
0.408 0.406 0.427
Expression systems:
  • Drosophila melanogaster
  • Spodoptera frugiperda