Function and Biology

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: glycerophospholipid biosynthetic process
Cellular component: cytosol

EC 2.7.1.82: Ethanolamine kinase

Reaction catalysed:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
Systematic name:
ATP:ethanolamine O-phosphotransferase
Alternative Name(s):
  • Ethanolamine kinase (phosphorylating)
  • Ethanolamine phosphokinase

EC 2.7.1.32: Choline kinase

Reaction catalysed:
ATP + choline = ADP + phosphocholine.
Comments:
  • Ethanolamine and its methyl and ethyl derivatives can also act as acceptors.
Systematic name:
ATP:choline phosphotransferase
Alternative Name(s):
  • Choline kinase (phosphorylating)
  • Choline phosphokinase
  • Choline-ethanolamine kinase

Sequence family

Pfam Protein family (Pfam)
PF01633
Domain description: Choline/ethanolamine kinase
Occurring in:
  1. Choline/ethanolamine kinase
1 copy of Pfam domain PF01633 (Choline/ethanolamine kinase) in Choline/ethanolamine kinase in PDB 3lq3.

InterPro InterPro annotations
IPR026712
Domain description: Choline/Ethanolamine kinase
Occurring in:
  1. Choline/ethanolamine kinase
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Choline/ethanolamine kinase
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Choline/ethanolamine kinase

Structure domain

CATH CATH domain
3.90.1200.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Homology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Occurring in:
  1. Choline/ethanolamine kinase
1 copy of CATH domain 3.90.1200.10 (Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2) in Choline/ethanolamine kinase in PDB 3lq3.