Structure analysis

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

X-ray diffraction
1.42Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 31100 Å2
Buried surface area: 7700 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 9 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -91 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 401 amino acids
Theoretical weight: 46.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y259 (Residues: 14-395; Coverage: 97%)
Gene names: CHETK, CHKB, CHKL
Pfam: Choline/ethanolamine kinase
InterPro:
CATH: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2

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