PDBe 3lq3

X-ray diffraction
1.42Å resolution

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

Released:

Function and Biology Details

Reactions catalysed:
ATP + choline = ADP + phosphocholine. 
ATP + ethanolamine = ADP + O-phosphoethanolamine. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline/ethanolamine kinase Chain: A
Molecule details ›
Chain: A
Length: 401 amino acids
Theoretical weight: 46.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y259 (Residues: 14-395; Coverage: 97%)
Gene names: CHETK, CHKB, CHKL
Sequence domains: Choline/ethanolamine kinase
Structure domains: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 98.175Å b: 73.206Å c: 62.426Å
α: 90° β: 117.97° γ: 90°
R-values:
R R work R free
0.188 0.187 0.213
Expression system: Escherichia coli BL21(DE3)