PDBe 3llt

X-ray diffraction
2.5Å resolution

Crystal structure of PF14_0431, kinase domain.

Released:
Source organism: Plasmodium falciparum 3D7
Entry authors: Wernimont AK, Tempel W, Lin YH, Loppnau P, MacKenzie F, Sullivan H, Weadge J, Kozieradzki I, Cossar D, Sinesterra G, Vedadi M, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Hui R, Qiu W, Hutchinson A, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein serine/threonine kinase-1 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 42.19 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IL19 (Residues: 534-875; Coverage: 39%)
Gene names: LAMMER, PF14_0431, PF3D7_1445400
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P65
Unit cell:
a: 140.081Å b: 140.081Å c: 52.418Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.223 0.267
Expression system: Escherichia coli