PDBe 3lfy

X-ray diffraction
2.6Å resolution

CTD of Tarocystatin in complex with papain

Released:
Source organism: Carica papaya
Entry authors: Chu MH, Liu KL, Yeh KW, Cheng YS

Function and Biology Details

Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Papain Chains: A, C
Molecule details ›
Chains: A, C
Length: 212 amino acids
Theoretical weight: 23.5 KDa
Source organism: Carica papaya
UniProt:
  • Canonical: P00784 (Residues: 134-345; Coverage: 65%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P31
Unit cell:
a: 48.89Å b: 48.89Å c: 200.87Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.213 0.267