PDBe 3lfe

X-ray diffraction
2.3Å resolution

Human p38 MAP Kinase in Complex with RL116

Released:
Source organism: Homo sapiens
Entry authors: Gruetter C, Simard JR, Getlik M, Rauh D

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 68.63Å b: 70.16Å c: 74.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.274
Expression system: Escherichia coli