PDBe 3lcs

X-ray diffraction
1.95Å resolution

Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 38.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1072-1410; Coverage: 21%)
Gene name: ALK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 51.941Å b: 56.69Å c: 104.171Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.229
Expression system: Spodoptera frugiperda