PDBe 3lco

X-ray diffraction
3.4Å resolution

Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P07333 (Residues: 550-919; Coverage: 34%)
Gene names: CSF1R, FMS
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P43212
Unit cell:
a: 62.916Å b: 62.916Å c: 183.943Å
α: 90° β: 90° γ: 90°
R R work R free
0.247 0.245 0.289
Expression system: Spodoptera frugiperda