PDBe 3lcd

X-ray diffraction
2.5Å resolution

Inhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 37.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P07333 (Residues: 538-922; Coverage: 34%)
Gene names: CSF1R, FMS
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 57.649Å b: 74.125Å c: 91.024Å
α: 90° β: 90° γ: 90°
R R work R free
0.218 0.216 0.265
Expression system: Spodoptera frugiperda