Function and Biology

Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor binding
Biological process: immune response
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

CATH Protein families (Pfam)
PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family) in Tumor necrosis factor, soluble form in PDB 3l9j.

PF00059
Domain description: Lectin C-type domain
Occurring in:
  1. Tetranectin
1 copy of Pfam domain PF00059 (Lectin C-type domain) in Tetranectin in PDB 3l9j.

CATH InterPro annotations
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR001304
Domain description: C-type lectin-like
Occurring in:
  1. Tetranectin
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR008983
Domain description: Tumour necrosis factor-like domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR016186
Domain description: C-type lectin-like/link domain
Occurring in:
  1. Tetranectin
IPR016187
Domain description: C-type lectin fold
Occurring in:
  1. Tetranectin
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form

Structure domains

CATH CATH domains
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form in PDB 3l9j.
3.10.100.10
Class: Alpha Beta
Architecture: Roll
Topology: Mannose-Binding Protein A; Chain A
Homology: Mannose-Binding Protein A, subunit A
Occurring in:
  1. Tetranectin
1 copy of CATH domain 3.10.100.10 (Mannose-Binding Protein A; Chain A) in Tetranectin in PDB 3l9j.