PDBe 3l81

X-ray diffraction
1.6Å resolution

Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AP-4 complex subunit mu-1 Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00189 (Residues: 160-453; Coverage: 65%)
Gene names: AP4M1, MUARP2
Sequence domains: Adaptor complexes medium subunit family
Structure domains: Immunoglobulin-like
C31 Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 963 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 761-767; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D, APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 46.672Å b: 56.91Å c: 60.664Å
α: 90° β: 106.53° γ: 90°
R-values:
R R work R free
0.209 0.207 0.252
Expression systems:
  • Escherichia coli
  • Not provided