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Crystal complex of N-terminal Human Maltase-Glucoamylase with BJ2661

Source organism: Homo sapiens
Biochemical function: carbohydrate binding
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 3.2.1.20: Alpha-glucosidase

Reaction catalysed:
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose
Systematic name:
Alpha-D-glucoside glucohydrolase
Alternative Name(s):
  • Acid maltase
  • Alpha-1,4-glucosidase
  • Alpha-D-glucosidase
  • Alpha-glucopyranosidase
  • Alpha-glucoside hydrolase
  • Glucoinvertase
  • Glucosidoinvertase
  • Glucosidosucrase
  • Lysosomal alpha-glucosidase
  • Maltase
  • Maltase-glucoamylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF21365
Domain description: Glycosyl hydrolase family 31 C-terminal domain
Occurring in:
  1. Maltase-glucoamylase

PF01055
Domain description: Glycosyl hydrolases family 31 TIM-barrel domain
Occurring in:
  1. Maltase-glucoamylase
The deposited structure of PDB entry 3l4t contains 1 copy of Pfam domain PF01055 (Glycosyl hydrolases family 31) in Maltase-glucoamylase. Showing 1 copy in chain A.

PF13802
Domain description: Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain
Occurring in:
  1. Maltase-glucoamylase

PF00088
Domain description: Trefoil (P-type) domain
Occurring in:
  1. Maltase-glucoamylase
The deposited structure of PDB entry 3l4t contains 1 copy of Pfam domain PF00088 (Trefoil (P-type) domain) in Maltase-glucoamylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000519
Domain description: P-type trefoil domain
Occurring in:
  1. Maltase-glucoamylase
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Maltase-glucoamylase
IPR030459
Domain description: Glycosyl hydrolases family 31, conserved site
Occurring in:
  1. Maltase-glucoamylase
IPR030458
Domain description: Glycosyl hydrolases family 31, active site
Occurring in:
  1. Maltase-glucoamylase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Maltase-glucoamylase
IPR000322
Domain description: Glycoside hydrolase family 31, TIM barrel domain
Occurring in:
  1. Maltase-glucoamylase
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Maltase-glucoamylase
IPR017957
Domain description: P-type trefoil, conserved site
Occurring in:
  1. Maltase-glucoamylase
IPR044913
Domain description: P-type trefoil domain superfamily
Occurring in:
  1. Maltase-glucoamylase

Structure domains

CATH CATH domains
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Maltase-glucoamylase
The deposited structure of PDB entry 3l4t contains 2 copies of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Maltase-glucoamylase. Showing 2 copies in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Maltase-glucoamylase
The deposited structure of PDB entry 3l4t contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in Maltase-glucoamylase. Showing 1 copy in chain A.
2.60.40.1760
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: glycosyl hydrolase (family 31)
Occurring in:
  1. Maltase-glucoamylase
The deposited structure of PDB entry 3l4t contains 1 copy of CATH domain 2.60.40.1760 (Immunoglobulin-like) in Maltase-glucoamylase. Showing 1 copy in chain A.
4.10.110.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Spasmolytic Protein; domain 1
Homology: Spasmolytic Protein, domain 1
Occurring in:
  1. Maltase-glucoamylase
The deposited structure of PDB entry 3l4t contains 1 copy of CATH domain 4.10.110.10 (Spasmolytic Protein; domain 1) in Maltase-glucoamylase. Showing 1 copy in chain A.

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