PDBe 3l4r

X-ray diffraction
1.45Å resolution

Crystal structure of the dog lipocalin allergen Can f 2 and implications for cross-reactivity to the cat allergen Fel d 4


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Minor allergen Can f 2 Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.47 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O18874 (Residues: 19-180; Coverage: 100%)
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2221
Unit cell:
a: 68.175Å b: 76.898Å c: 64.996Å
α: 90° β: 90° γ: 90°
R R work R free
0.158 0.157 0.168
Expression system: Escherichia coli BL21(DE3)