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Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with activator, diadenosine tetraphosphate

Source organism: Clostridium perfringens str. 13
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.1.1: Inorganic diphosphatase

Reaction catalysed:
Diphosphate + H(2)O = 2 phosphate
Systematic name:
Diphosphate phosphohydrolase
Alternative Name(s):
  • Inorganic pyrophosphatase
  • Pyrophosphate phosphohydrolase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00571
Domain description: CBS domain
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
The deposited structure of PDB entry 3l2b contains 4 copies of Pfam domain PF00571 (CBS domain) in Cobalt-dependent inorganic pyrophosphatase. Showing 2 copies in chain A.

PF01368
Domain description: DHH family
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
The deposited structure of PDB entry 3l2b contains 4 copies of Pfam domain PF01368 (DHH family) in Cobalt-dependent inorganic pyrophosphatase. Showing 2 copies in chain A.

PF07085
Domain description: DRTGG domain
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
The deposited structure of PDB entry 3l2b contains 2 copies of Pfam domain PF07085 (DRTGG domain) in Cobalt-dependent inorganic pyrophosphatase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000644
Domain description: CBS domain
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
IPR028979
Domain description: HPr(Ser) kinase/phosphorylase-like, N-terminal domain superfamily
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
IPR046342
Domain description: CBS domain superfamily
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
IPR010766
Domain description: DRTGG
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase

Structure domains

CATH CATH domains
3.10.580.10
Class: Alpha Beta
Architecture: Roll
Topology: CBS-domain
Homology: CBS-domain
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
The deposited structure of PDB entry 3l2b contains 2 copies of CATH domain 3.10.580.10 (CBS-domain) in Cobalt-dependent inorganic pyrophosphatase. Showing 1 copy in chain A.
3.40.1390.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1
Homology: HprK N-terminal domain-like
Occurring in:
  1. Cobalt-dependent inorganic pyrophosphatase
The deposited structure of PDB entry 3l2b contains 2 copies of CATH domain 3.40.1390.20 (Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1) in Cobalt-dependent inorganic pyrophosphatase. Showing 1 copy in chain A.

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