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Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK - Wild type FlK in complex with fluoro-acetate

Source organism: Streptomyces cattleya
Biochemical function: protein homodimerization activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.2.29: Fluoroacetyl-CoA thioesterase

Reaction catalysed:
Fluoroacetyl-CoA + H(2)O = fluoroacetate + CoA
Systematic name:
Fluoroacetyl-CoA hydrolase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR025540
Domain description: Fluoroacetyl-CoA thioesterase
Occurring in:
  1. Fluoroacetyl-CoA thioesterase
IPR029069
Domain description: HotDog domain superfamily
Occurring in:
  1. Fluoroacetyl-CoA thioesterase

Structure domain

CATH CATH domain
3.10.129.10
Class: Alpha Beta
Architecture: Roll
Topology: Thiol Ester Dehydrase; Chain A
Homology: Hotdog Thioesterase
Occurring in:
  1. Fluoroacetyl-CoA thioesterase
The deposited structure of PDB entry 3kv8 contains 2 copies of CATH domain 3.10.129.10 (Thiol Ester Dehydrase; Chain A) in Fluoroacetyl-CoA thioesterase. Showing 1 copy in chain A.

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