PDBe 3kul

X-ray diffraction
2.15Å resolution

Kinase domain of human ephrin type-A receptor 8 (EPHA8)

Released:
Source organism: Homo sapiens
Entry authors: Walker JR, Yermekbayeva L, Kania J, Bountra C, Weigelt J, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 8 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29322 (Residues: 602-909; Coverage: 32%)
Gene names: EEK, EPHA8, HEK3, KIAA1459
Sequence domains: Protein tyrosine kinase
Structure domains:
Ephrin type-A receptor 8 Chain: B
Molecule details ›
Chain: B
Length: 325 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29322 (Residues: 602-909; Coverage: 32%)
Gene names: EEK, EPHA8, HEK3, KIAA1459
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 44.14Å b: 41.879Å c: 145.815Å
α: 90° β: 92.46° γ: 90°
R-values:
R R work R free
0.19 0.187 0.244
Expression system: Escherichia coli BL21(DE3)