PDBe 3ks9

X-ray diffraction
1.9Å resolution

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

Released:
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Khutoreskaya G, Seitova A, Cossar D, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 496 amino acids
Theoretical weight: 55.69 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q13255 (Residues: 28-518; Coverage: 42%)
Gene names: GPRC1A, GRM1, MGLUR1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 79.23Å b: 96.546Å c: 97.545Å
α: 90° β: 106.67° γ: 90°
R-values:
R R work R free
0.207 0.206 0.241
Expression system: unidentified baculovirus