› 3kry

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-155286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 18.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 104-267; Coverage: 36%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:
Ligand ZN 8 x ZN
Ligand CA 8 x CA
Ligand 3KR 4 x 3KR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P1
Unit cell:
a: 36.317Å b: 70.016Å c: 69.094Å
α: 92.42° β: 94.23° γ: 104.94°
R-values:
R R work R free
0.209 0.206 0.256
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.
Zhang et al. (2011)
8 more

1 mention without citation

Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening.
Gimeno et al. (2021)