PDBe 3krr

X-ray diffraction
1.8Å resolution

Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 840-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 93.312Å b: 103.009Å c: 68.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.206
Expression system: Spodoptera frugiperda